SageDIA: A Fast DIA analysis engine, tailored for high-resolution, high-throughput workflows

SageDIA leverages many of the high-performance core algorithms developed in SageDDA, adapting them to address the unique challenges of DIA data. It employs a hybrid approach that combines spectrum-centric and peptide-centric analysis techniques, delivering fast performance while maintaining high identification sensitivity and accuracy. Its neural network–based peptide detection strategies enable confident quantification across complex datasets. Additionally, SageDIA supports light-heavy labeled sample analysis, making it an ideal tool for both discovery-driven and comparative proteomics.